Follistatin-like 1 in Cardiovascular Disease and Inflammation

Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity

Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes. However, the molecular mechanisms that link obesity to inflammation are not fully understood. Follistatin-like 1 (FSTL1) is a novel proinflammatory cytokine that is expressed in adipose tissue and secreted by preadipocytes/adipocytes. We aimed to test whether FSTL1 ...

Inflammation and cardiovascular disease

There now exists overwhelming evidence supporting the inflammatory hypothesis of atherosclerotic vascular disease. Cellular interactions between leukocytes, platelets and endothelial cells are critical in the initiation and progression of atherosclerotic disease. Acute coronary syndromes, namely unstable angina and acute myocardial infarction, and thromboembolic stroke represent acute unstable ...

Inflammation in Cardiovascular Disease

In 1998, I wrote an editorial that attempted to make two points.2 The first point was biological: there existed at that time an active debate over whether inflammation was a cause or a result of cardiovascular disease (CVD), and I suggested that this debate was in fact based on a false distinction, and that both positions where likely to be correct. While atherothrombotic disease is inflammator...

Inflammation in Cardiovascular Disease

Heme oxygenase-1 in inflammation and cardiovascular disease.

Cardiovascular disease accounts for 1 of every 2.9 deaths in the United States, thus the burden of the disease remains high. Given the high mortality and escalating healthcare cost for the disease, it is of urgent need to treat cardiovascular disease effectively. Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate carbon monoxide, biliverdin, and iron. These reaction products of...